$30M commitment supports development of therapies for viral infections

first_img From the lab to COVID front lines AbbVie will provide $30 million over three years and additional in-kind support leveraging AbbVie’s scientists, expertise and facilities to advance collaborative research and early-stage development efforts across five program areas that address a variety of therapeutic modalities:Immunity and immunopathology — Study of the fundamental processes that impact the body’s critical immune responses to viruses and identification of opportunities for therapeutic intervention.Led by Uli Von Andrian, Mallinckrodt Professor of Immunopathology in the Blavatnik Institute at HMS and program leader of basic immunology at the Ragon Institute of MGH, MIT, and Harvard; and by Jochen Salfeld, vice president, immunology and virology discovery at AbbVie.Host targeting for antiviral therapies — Development of approaches that modulate host proteins in an effort to disrupt the life cycle of emergent viral pathogens.Led by Pamela Silver, Elliot T. and Onie H. Adams Professor of Biochemistry and Systems Biology in the Blavatnik Institute at HMS; and by Steve Elmore, vice president, drug discovery science and technology at AbbVie.Antibody therapeutics — Rapid development of therapeutic antibodies or biologics against emergent pathogens, including SARS-CoV-2, to a preclinical or early-clinical stage.Led by Jonathan Abraham, assistant professor of microbiology in the Blavatnik Institute at HMS; and by Jochen Salfeld, vice president, immunology and virology discovery at AbbVie.Small molecules — Discovery and early-stage development of small-molecule drugs that would act to prevent replication of known coronaviruses and emergent pathogens.Led by Mark Namchuk, executive director of therapeutics translation at HMS and senior lecturer of biological chemistry and molecular pharmacology in the Blavatnik Institute at HMS; and by Steve Elmore, vice president, drug discovery science and technology at AbbVie.Translational development — Preclinical validation, pharmacological testing, and optimization of leading approaches, in collaboration with Harvard-affiliated hospitals, with program leads to be determined. $16.5 million awarded to projects to fight COVID Chan School’s Michael Mina urges federal regulatory approval, widespread use Technology developed at Harvard provides early boost to Mass. COVID testing Harvard University and AbbVie today announced a $30 million collaborative research alliance, launching a multi-pronged effort at Harvard Medical School (HMS) to study and develop novel therapies against emergent viral infections, with a focus on those caused by coronaviruses and by viruses that lead to hemorrhagic fever.This collaboration aims to rapidly integrate fundamental biology into the preclinical and clinical development of new therapies for viral diseases that address a variety of therapeutic modalities. HMS has led several large-scale, coordinated research efforts launched at the beginning of the COVID-19 pandemic.“A key element of having a strong R&D organization is collaboration with top academic institutions, like Harvard Medical School, to develop therapies for patients who need them most,” said Michael Severino, vice chairman and president of AbbVie. “There is much to learn about viral diseases and the best way to treat them. By harnessing the power of collaboration, we can develop new therapeutics sooner to ensure the world is better prepared for future potential outbreaks.”“The cataclysmic nature of the COVID-19 pandemic reminds us how vital it is to be prepared for the next public health crisis and how critical collaboration is on every level — across disciplines, across institutions, and across national boundaries,” said George Q. Daley, dean of Harvard Medical School. “Harvard Medical School, as the nucleus of an ecosystem of fundamental discovery and therapeutic translation, is uniquely positioned to propel this transformative research alongside allies like AbbVie.” Related MassCPR collaboration funds plans with promise to help in a year Cheap, frequent COVID tests could be ‘akin to vaccine,’ professor sayslast_img read more

US, Australia close borders for Chinese arrival

first_imgEarlier, more countries including Russia, Japan, Pakistan and Italyannounced identical travel restrictions. “Travelrestrictions can cause more harm than good by hindering info-sharing, medicalsupply chains and harming economies,” the head of the World HealthOrganization (WHO) said on Friday. The WHOrecommends introducing screening at official border crossings. It has warnedthat closing borders could accelerate the spread of the virus, with travelersentering countries unofficially.(BBC)center_img THE United States and Australiaannounced that they would deny entry to all foreign visitors who had recentlyvisited China, the origin of the virus that emerged last December.last_img read more

Proline defeat Kyetume to take control of Uganda Cup semi

first_imgProline players celebrate Mujuzi’s second goal against Kyetume. (Proline Photos)Uganda Cup 2018/19Kyetume FC 1-2 Proline FCNakisunga Ssaza playground, MukonoMonday, 29-04-2019MUKONO – Proline moved closer to a first ever Uganda Cup final following a 2-1 win away to Kyetume in the semi final first leg.In the game played at Nakisunga playgrounds on Monday, Proline raced into a 2-0 lead.First it was Ibrahim Bonyo who slotted in the opener on 24 minutes after he was played in by another Ibrahim, Wamanah.Mustafa Mujuzi doubled the visitors’ advantage in the second half, from a beautiful free kick that left Kyetume goalkeeper Ismail Zziwa rooted to the spot.Later on in the game, Robert Ssentongo halved the deficit off an Elkanah Ndugwa lobbed pass that caught Proline’s defence flat.“It’s a big win for us, said Proline’s coach Shafic Bisaso after the game.“We benefited from the little we know about our opponents but it is not yet over as there are still 90 minutes away.Despite taking a 2-0 comfortable lead, Kyetume’s veterans – Vincent Kayizi, Patrick Ochan, Robert Ssentongo and Elkana Ndugwa – kept pressing but Proline managed to hold on for a win.Proline who eliminated Vipers will have goalkeeper Hassan Matovu to thank after the KCCA FC loanee kept out three rocket freekicks from Benon Tahomera.Towering striker Faisaam Malango also headed out Robert Ssentongo’s lofty delivery.Proline could have sealed it there and then but Bonyo who was freed by substitute Bright Anukani, fluffed his keeper-to-beat attempt over the bar.In the end, Proline walked out of Nakisunga with their heads held high after registering a vital win away from home.The two sides will clash again in the return leg at Lugogo earlier next month.The other semi final first leg between Bright Stars and Express ended 1-1 at the Champions Stadium in Mwerere, on Sunday.Comments Tags: Elkanah NkugwaIbrahim BonyoIbrahim WamanahKyetume FCMustafa Mujuziproline fcRobert SsentongoShafick Bisasotoplast_img read more

Infrastructure to be Upgraded at Enid Bennett High School

first_img “That is going to make sure you achieve your vision, whether it is your auditorium or whatever else it is that you want to do. The Regional [office] will now work with you to do the design work, so that whatever it is that we want to do, along with your strategic plan, to make sure that this institution, in honour of Enid Bennett, becomes a world class institution,” the Minister said. The undertaking was given during his address at the renaming ceremony for the school from Bog Walk High School to the Enid Bennett High School on Tuesday (June 19). Minister of Education, Youth and Information, Senator the Hon. Ruel Reid, has committed to spend $20 million annually for the next three years to upgrade the infrastructure at the Enid Bennett High School, in St. Catherine.The undertaking was given during his address at the renaming ceremony for the school from Bog Walk High School to the Enid Bennett High School on Tuesday (June 19).“That is going to make sure you achieve your vision, whether it is your auditorium or whatever else it is that you want to do. The Regional [office] will now work with you to do the design work, so that whatever it is that we want to do, along with your strategic plan, to make sure that this institution, in honour of Enid Bennett, becomes a world class institution,” the Minister said.Senator Reid said that the Ministry would also be providing funds to help youth who are in need and are currently attending the school.“One million dollars will go toward your boys’ empowerment programme and $4 million towards your science programme,” he said.“I have come as a partner to work with you to drive the vision of excellence for Bog Walk High School, now the Enid Bennett High School, and for all the other educational institutions in Jamaica,” the Minister added.The late Enid Bennett was born in Linstead on May 18, 1931. She started her education at Linstead Primary School and later attended St. Helen Commercial School, where she qualified as a stenographer.She was elected Councillor for the Sligoville division and later Member of Parliament for Central St. Catherine, before moving to represent St. Catherine West Central.Miss Bennett served as Minister of State in the Ministry of Local Government between 1980 and 1982, and Minister of State in the Ministry of Labour and Social Security between 1982 and 1989. She was awarded the country’s fourth highest honour, the Order of Jamaica, in 2012.Miss Bennett is hailed as a trailblazing politician, serving as Member of Parliament for 30 continuous years until her retirement in 1997, and setting a record as a female legislator in the House of Representatives.Throughout her years of service in politics, she aimed to transform the lives of citizens and was instrumental in establishing community centres in Buxton Town and Point Hill, improving the West Central St. Catherine road network and bringing electricity to several communities in the constituency.Ms. Bennett died on December 22, 2017 at age 86 after a brief illness. Minister of Education, Youth and Information, Senator the Hon. Ruel Reid, has committed to spend $20 million annually for the next three years to upgrade the infrastructure at the Enid Bennett High School, in St. Catherine. Story Highlightslast_img read more

APPLICATIONS ARE NOW OPEN FOR THE 2019 CMPA INDIESCREEN AWARDS

first_imgAdvertisement Login/Register With: APPLICATIONS ARE NOW OPEN FOR THE 2019 CMPA INDIESCREEN AWARDS!CLICK HERE FOR ADDITIONAL INFORMATION AND/OR TO SUBMIT.ELIGIBILITY CRITERIA Advertisement Facebook • Applicant(s) must have or have had a feature film screening in either 2018 or 2019 at one of the following 4 festivals:– Toronto International Film Festival– Calgary International Film Festival– FIN: Atlantic International Film Festival– Vancouver International Film Festival• Those who previously applied for the 2018 Indiescreen Awards may do so again this year. However, 2018 Indiescreen Awards nominees are not eligible to reapply.• The qualifying film must have a runtime of at least 60 minutes.• The eligible festival selection must be a Canadian film; in the case of co-productions, the film must be a majority Canadian production.• Only the lead producer (or producing team) may apply.• In the event that there is a producing team wishing to submit an application, the team must have made at least 3 features films together. Otherwise, the team must choose a producer to submit in the category for which they are eligible.• A film cannot be submitted more than once, meaning it cannot be submitted in both the established and emerging categories.• Applicant producer(s) must be a Canadian citizen or a permanent resident of Canada• The Established Producer Award, presented annually since 2006, recognizes a Canadian independent feature film producer’s body of work, as well as their contribution toward defining the reputation of Canadian cinema on the world stage.– – Producers wishing to apply for the Established Producer Award must have produced at least three feature films over the course of their career. This includes their eligible festival selection.• The Emerging Producer Award, renamed the Kevin Tierney Emerging Producer Award, was added to the CMPA awards program in 2016 to highlight the extraordinary talents of an up-and-coming producer with bright career prospects.– – Producers wishing to apply for the Kevin Tierney Emerging Producer Award must have produced two feature films or fewer over the course of their career. This includes their eligible festival selection.• Previous winners of the Established Producer Award (or the CMPA Feature Film Producer Award) are welcome to reapply five years after their award win. Emerging Producer Award winners may apply again after three years.• Applicants are not required to be CMPA members.DEADLINE FOR SUBMISSIONSAUGUST 9, 2019 12 PM ESTCLICK HERE FOR ADDITIONAL INFORMATION AND/OR TO SUBMIT LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement Twitterlast_img read more

Live By The Three Die By The Three Is Mostly A Myth

Were the Warriors just unlucky? Their opponents, the Cleveland Cavaliers, were not a particularly good defensive team during the regular season, either overall or against perimeter shooters, although they may be better with Iman Shumpert and Matthew Dellavedova and Tristan Thompson getting more minutes because of injuries. The Cavs forced the Warriors into some bad possessions, but the Dubs also missed on some good looks, shooting just 2-for-11 on corner threes.But there’s also the old adage: Live by the three, die by the three. If your shooters are going to get crazy hot on some nights, isn’t it inevitable that they’ll shoot a bunch of bricks on another, rendering a team’s offense more inconsistent and making it more upset-prone?Let’s look at some data from the 2014-15 regular season. In the chart below, I’ve sorted teams by the percentage of their field goals that were taken from 3-point range. Then I’ve looked at their game-by-game scoring, calculating their scoring range (as I’ll describe it throughout this article) as the span including the middle 80 percent of their games (that is, throwing out their top 10 percent and bottom 10 percent of performances).The Warriors, for instance, averaged 110 points per game in the regular season, while their scoring range ran from 98 points (at the 10th percentile) to 126 points (at the 90th percentile), a 28-point difference. That seems like a wide range … but it’s perfectly normal. The average NBA team this season had a 27-point scoring range. The average range since 1979-80 (when the 3-point shot was introduced) is 28 points.The Warriors weren’t the league’s most three-happy team, however. They were just seventh — behind the Houston Rockets, Cleveland Cavaliers, Los Angeles Clippers, Atlanta Hawks, Philadelphia 76ers and Portland Trail Blazers. So maybe the Dubs were pretty steady, but were those other teams inconsistent?The Cavaliers were inconsistent: Their scoring range spanned 33 points, tied for the second-highest total in the league after Oklahoma City.2Like the Thunder, who dealt with injuries to Kevin Durant and Russell Westbrook, the Cavs went through numerous lineup changes and new “looks” over the course of the regular season. So that may reflect personnel changes more than inconsistency per se. But Houston, which took 39 percent of its attempts from long range (easily an NBA record), had a scoring range of just 25 points, below the NBA average. The three-happy Atlanta Hawks had a scoring range of just 24 points.What’s going on here? Are teams that shoot a lot of threes actually more consistent than others? (Maybe they’re more resilient when facing different types of defenses or benefit from having better floor spacing?)Actually, it’s mostly just because this data is pretty noisy. I ran a regression on all NBA teams since 1979-80 to predict their scoring range based on (i) the percentage of their field goal attempts that came from behind the arc and (ii) their per-game scoring average. Both variables have a positive and highly statistically significant relationship with a team’s scoring range. Teams that score more points have a wider scoring range, and, once you control for that, teams that shoot more threes do also.But statistical significance is not the same thing as practical significance. In the context of an actual basketball team, this result will make very little difference.Suppose, for instance, that a team scores 100 points per game and that 40 percent of its field-goal attempts are 3-pointers — higher, even, than this year’s record-setting Rockets. Its scoring range, according to the regression analysis, projects to be 29.7 points.What about a team that scores 100 points but does so with only 10 percent of its shots being threes? No team has shot such a low percentage of 3-pointers since the 1999-2000 Philadelphia 76ers, but we’ll run the numbers just for fun. That team, according to the regression, would have a scoring range of 28.0 points. So it’s more consistent, but only barely so; its scoring range is only 6 percent narrower. This just really doesn’t matter much.What matters a lot more, of course, is how effective a team is at scoring overall. The Oklahoma City Thunder, as I mentioned, had the most inconsistent offense in the regular season. But their 10th percentile score, 88 points, was still better than two-thirds of the league because they had a high per game scoring average.And Golden State’s 10th percentile score, 98 points, was better than what almost a third of NBA teams scored on average per game. The Warriors will have better shooting nights than they did Sunday, but their bad nights aren’t indicative of a fundamental problem — they’re just bad nights.CORRECTION (June 9, 11:45 a.m.): An earlier version of this article incorrectly said that if the Golden State Warriors had made 3-pointers at their regular-season accuracy rate, they would have won Sunday’s NBA Finals game 117-95. They would have won 111-95. “You’ll shoot your eye out,” I kept thinking while watching Game 2 of the NBA Finals on Sunday. The Warriors hoisted 35 3-point attempts and made only eight of them en route to scoring just 93 points. It was a maddening, sloppy game full of what-ifs. So … what if the Warriors had sunk threes at their normal accuracy rate?1The Warriors shot .398 on 3-pointers during the regular season, which would equate to making 14 of 35 shots. They would have won 111-95. read more

Marine Corps recruit dies after unspecified medical emergency

first_imgMarine Corps recruit dies after unspecified ‘medical emergency’ KUSI Newsroom, KUSI Newsroom SAN DIEGO (KUSI)  — A recruit at the Marine Corps Recruit Depot San Diego has died after being hospitalized for an unspecified “medical emergency,” corps officials said Sunday.The recruit was pronounced dead at 11:43 a.m. Sunday, officials said. He had been admitted to an off-base hospital on Saturday after a medical incident that occurred around midnight Friday.Details were scant, but a drill instructor performed CPR on the recruit experiencing the emergency before paramedics arrived and took him to an off-base medical facility, according to a Marine Corps statement on Saturday.The cause of the health emergency has not been identified, but the recruit was being monitored due to ongoing physical health issues, officials said.“Supporting the recruit’s family is our top priority and we continue to work closely with them during this most difficult time,” said Brig. Gen. William Jurney, the recruit depot’s commanding general.Military officials said they would withhold the recruit’s identity until 24 hours after notifications of next-of-kin. March 25, 2018 Posted: March 25, 2018 Categories: Local San Diego News FacebookTwitterlast_img read more